Browsing by Author "Lladser, Álvaro"

Now showing items 1-7 of 7

    • CD73 ectonucleotidase restrains CD8+T cell metabolic fitness and anti-tumoral activity 
      Briceño Catalán, Pedro Felipe; Rivas Yáñez, Elizabeth Camila; Rosemblatt Bono, Mariana Violeta; Parra Tello, Brian Josué; Farías, Paula; Vargas, Leonardo; Simon Zegers, María Valeska; Cárdenas, César; Lladser, Álvaro; Salazar Onfray, Flavio Andrés; Elorza, Álvaro A.; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Sauma Mahaluf, Daniela Macarena (Frontiers Media, 2021)
      CD39 and CD73 are ectoenzymes that dephosphorylate ATP into its metabolites; ADP, AMP, and adenosine, and thus are considered instrumental in the development of immunosuppressive microenvironments. We have previously shown ...
    • E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells 
      Lobos González, Lorena; Aguilar, Lorena; Díaz Jara, Jorge; Díaz, Natalia; Urra, Hery; Torres Gómez, Vicente; Silva, Verónica; Fitzpatrick, Christopher; Lladser, Álvaro; Hoek, Keith S.; Leyton Campos, Lisette; Quest, Andrew F. G. (2013)
      Theroleofcaveolin-1(CAV1)incancerishighlycontroversial.CAV1suppressesgenesthatfavortumordevelopment, yet also promotes focal adhesion turnover and migration of metastatic cells. How these contrasting observations relate ...
    • Ecto-5′-nucleotidase (CD73) regulates the survival of CD8+ T cells 
      Rosemblatt Bono, Mariana Violeta; Parra Tello, Brian Josué; Briceño Catalán, Pedro Felipe; Rivas Yáñez, Elizabeth Camila; Tucer, Suat; Saavedra Almarza, Juan Pablo; Hormann Cornejo, Pilar Leonor; Martínez, Brandon A.; Lladser, Álvaro; Rosemblatt Silber, Mario César; Cekic, Caglar; Bono Merino, María Rosa; Sauma Mahaluf, Daniela Macarena (Frontiers Media, 2021)
      Ecto-5 '-nucleotidase (CD73) is an enzyme present on the surface of tumor cells whose primary described function is the production of extracellular adenosine. Due to the immunosuppressive properties of adenosine, CD73 is ...
    • Efecto de las proteínas de virus Andes (Hantaviridae) sobre la apoptosis mediada por TRAIL 
      Segovia Pavez, Raúl Emilio. (Universidad de Chile, 2018)
      El virus Andes (ANDV) pertenece al género Orthohantavirus (familia Hantaviridae, orden Bunyavirales). En humanos la infección por ANDV produce el síndrome pulmonar asociado a hantavirus, el cual presenta una tasa de ...
    • Intradermal DNA electroporation induces survivin-speciWc CTLs, suppresses angiogenesis and confers protection ... 
      Lladser, Álvaro; Ljungberg, Karl; Tufvesson, Helena; Tazzari, Marcella; Roos, Anna-Karin; Quest, Andrew F. G.; Kiessling, Rolf (Springer-Verlag, 2010)
      Survivin is an intracellular tumor-associated antigen that is broadly expressed in a large variety of tumors and also in tumor associated endothelial cells but mostly absent in diVerentiated tissues. Naked DNA ...
    • Use of an "acetaldehyde clamp" in the determination of low-K-M aldehyde dehydrogenase activity in H4-II-E-C3 ... 
      Moncada, Claudio; Fuentes, Nelson; Lladser, Álvaro; Encina, Gonzalo; Sapag, Amalia; Karahanian, Eduardo; Israel Jacard, Yedy (PERGAMON-ELSEVIER SCIENCE LTD, 2003-08)
      The high-affinity (K-M < 1 muM) mitochondrial class 2 aldehyde dehydrogenase (ALDH2) metabolizes most of the acetaldehyde generated in the hepatic oxidation of ethanol. H4-II-E-C3 rat hepatoma cells have been found to ...
    • Vaccination-induced skin-resident memory CD8(+) T cells mediate strong protection against cutaneous melanoma 
      Gálvez Cancino, Felipe; López, Ernesto; Menares, Evelyn; Díaz, Ximena; Zapata Flores, Camila; Cáceres, Pablo; Hidalgo, Sofía; Chovar, Ornella; Alcántara Hernández, Marcela; Borgna, Vicenzo; Varas Godoy, Manuel; Salazar Onfray, Flavio; Idoyaga, Juliana; Lladser, Álvaro (Taylor & Francis, 2018)
      Memory CD8(+) T cell responses have the potential to mediate long-lasting protection against cancers. Resident memory CD8(+) T (Trm) cells stably reside in non-lymphoid tissues and mediate superior innate and adaptive ...